Dx'd with Parkinson's Dz 10/09 & MGUS 11/09 (14% plasma cells in bone marrow). Velcade, Dex, Rev lowered M protein, sx's of Parkinsons better but was still on Requip & gradually increasing doses of Carba/levo as M-protein rose over past 2 years. Ended up on nmassive doses of Parkinson meds.
Started Chemo(Kyprolis) 12 weeks ago (3 on 1 off week). Terrible increase in Parkinson sx's day of chemo through 3rd day post. Then tremendous decrease in need for Parkinson meds. Neurologist & Hematologist convinced it's PARKISONISM from paraneoplastic effect of monoclonal IgG. CSF shows presence of IgG.
Increase in sx's post chemo DUE TO TUMOR LYSIS. No other explanation fits. Parkinson Disease patients never significantly decrease their meds. I asked Neurologist what prompted him to order SPEP in the workup of my Parkinson's Dz...he said, "I had a hunch." I should be off all Parkinson meds in the 2 months.
Anyone else out there? Mike
- Michael Payne
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